扩张型心肌病患者的HLA - DRB1基因多态性

HLA-DRB1 gene polymorphism in patients with dilated cardiomyopathy.

作者信息

Wang Q, Liao Y, Gong F, Mao H, Zhang J

机构信息

Department of Cardiology, Institute of Cardiovascular Diseases, Tongji Medical University, Wuhan 430022.

出版信息

J Tongji Med Univ. 2000;20(2):141-2. doi: 10.1007/BF02887055.

DOI:10.1007/BF02887055

PMID:12845730

Abstract

To probe into the genetic background and immunopathogenesis of dilated cardiomyopathy (DCM), HLA-DRB1 gene polymorphism in 68 patients with DCM and 175 normal control subjects were analyzed by using the polymerase chain reaction/sequence specific primer (PCR/SSP) techniques. It was found that the frequencies of HLA-DRB1* 15 and HLA-DRB1* 03 alleles were significantly lower in DCM patients than those in normal controls (14.71% vs 29.71% and 4.41% vs 15.43%, respectively), the relative risks (RR) in the DCM patients being 0.41 and 0.25, respectively, all P < 0.05. However, the frequencies of HLA-DRB1* 11 and HLA-DRB1* 12 alleles were significantly higher in the DCM patients than in controls (29.4% vs 12.00% and 36.76% vs 12.57%, respectively) with the RR in the DCM patients being 3.06 and 4.04, respectively, all P < 0.01. These findings further demonstrated that immunogenetics might play a predominant pathogenetic role in partial DCM patients.

摘要

为探讨扩张型心肌病（DCM）的遗传背景及免疫发病机制，采用聚合酶链反应/序列特异性引物（PCR/SSP）技术分析了68例DCM患者和175例正常对照者的HLA-DRB1基因多态性。结果发现，DCM患者中HLA-DRB115和HLA-DRB103等位基因频率显著低于正常对照者（分别为14.71%对29.71%和4.41%对15.43%），DCM患者的相对危险度（RR）分别为0.41和0.25，均P<0.05。然而，DCM患者中HLA-DRB111和HLA-DRB112等位基因频率显著高于对照者（分别为29.4%对12.00%和36.76%对12.57%），DCM患者的RR分别为3.06和4.04，均P<0.01。这些发现进一步表明免疫遗传学可能在部分DCM患者的发病机制中起主要作用。