Department of Cardiology, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China.
Mol Biol Rep. 2012 Jan;39(1):221-6. doi: 10.1007/s11033-011-0729-y. Epub 2011 May 10.
Idiopathic dilated cardiomyopathy (IDC) has been hypothesized as a multifactorial disorder initiated by an environment trigger in individuals with predisposing human leukocyte antigen (HLA) alleles. Published data on the association between HLA-DR polymorphism and IDC risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 19 case-control studies including 1,378 cases and 10,383 controls provided data on the association between HLA-DR polymorphism and genetic susceptibility to IDC. Overall, statistically elevated frequencies of HLA-DR4 (OR 1.58; 95% CI 1.21-2.07; P=0.0009) and HLA-DR5 (OR 1.35; 95% CI 1.05-1.73; P=0.02) alleles were found in patients with IDC compared with controls. Individuals with HLA-DR3 antigen have a protective effect against IDC (OR 0.72; 95% CI 0.58-0.90; P=0.004). In summary, this meta-analysis indicated that certain HLA-DR alleles may be genetic markers for susceptibility and resistance to IDC.
特发性扩张型心肌病 (IDC) 被假设为由环境触发因素引发的多因素疾病，在具有易感性人类白细胞抗原 (HLA) 等位基因的个体中。关于 HLA-DR 多态性与 IDC 风险之间的关联，已有发表的数据尚无定论。为了更准确地评估这种关系，进行了荟萃分析。共有 19 项病例对照研究，包括 1378 例病例和 10383 例对照，提供了 HLA-DR 多态性与 IDC 遗传易感性之间关联的数据。总体而言，与对照组相比，IDC 患者 HLA-DR4（OR 1.58；95%CI 1.21-2.07；P=0.0009）和 HLA-DR5（OR 1.35；95%CI 1.05-1.73；P=0.02）等位基因的频率明显升高。具有 HLA-DR3 抗原的个体对 IDC 具有保护作用（OR 0.72；95%CI 0.58-0.90；P=0.004）。总之，这项荟萃分析表明，某些 HLA-DR 等位基因可能是 IDC 易感性和抗性的遗传标志物。
