[某些5-芳基乙炔基2'-脱氧尿苷衍生物的抗病毒活性]
[Antiviral activity of some 5-arylethynyl 2'-deoxyuridine derivatives].
作者信息
Andronova V L, Skorobogatyĭ M V, Manasova E V, Berlin Iu A, Korshun V A, Galegov G A
机构信息
Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, ul. Gamalei 16, Moscow, 123098 Russia.
出版信息
Bioorg Khim. 2003 May-Jun;29(3):290-5. doi: 10.1023/a:1023936516589.
5-(3-Perylenylethynyl)-2'-deoxyuridine was prepared by cross-linking 5-iodo-2'-deoxyuridine derivatives with 3-ethynylperylene followed by deprotection. 5-(1-Perylenylethynyl)-, 5-(3-perylenylethynyl)-, and 5-[4-(2-benzoxazolyl)phenylethynyl]-2'-deoxyuridine were found to inhibit in Vero cells the replication of type 1 herpes simplex virus and its drug-resistant strains.
5-(3-苝乙炔基)-2'-脱氧尿苷是通过将5-碘-2'-脱氧尿苷衍生物与3-乙炔基苝交联，然后脱保护制备而成。发现5-(1-苝乙炔基)-、5-(3-苝乙炔基)-和5-[4-(2-苯并恶唑基)苯乙炔基]-2'-脱氧尿苷在Vero细胞中可抑制1型单纯疱疹病毒及其耐药菌株的复制。
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