Schwöbel W, Streissle G, Kiefer G
Chemotherapy. 1979;25(5):268-78. doi: 10.1159/000237850.
Plaque reduction (PR) and persistent infection cell culture (PICC) tests were used as a standard procedure for the selection of effective and well-tolerated antiviral compounds. Antiviral activity and cytotoxicity as well as other characteristics of the test compound, i.e., the development of drug resistance or the potential for activating the multiplication of other viruses can be examined by this method. In the described system analogues of 2'-deoxyuridine were tested against herpes simplex virus.
噬斑减少（PR）试验和持续感染细胞培养（PICC）试验被用作筛选有效且耐受性良好的抗病毒化合物的标准程序。通过该方法可以检测受试化合物的抗病毒活性、细胞毒性以及其他特性，即耐药性的产生或激活其他病毒增殖的可能性。在所描述的系统中，对2'-脱氧尿苷类似物进行了抗单纯疱疹病毒的测试。
