Caksen Hüseyin, Deda Gülhis, Berberoğlu Merih, Içağasioğlu Dilara, Turan Ebru Bilge
Departments of Pediatrics, Yüzüncü Yil University Faculty of Medicine, Van, Turkey.
Acta Paediatr Taiwan. 2003 Mar-Apr;44(2):82-3.
In this article we studied serum leptin levels in children receiving long-term carbamazepine (CBZ) therapy (mean 3.4 years) to determine whether or not there was a relationship between serum leptin level and CBZ therapy. The study includes 14 patients followed with the diagnosis of epilepsy and treated long term CBZ, and 19 healthy children. Only two (14%) patients complained about overeating and weight gain. We did not find any significant difference for age, sex, body mass index and serum leptin levels between the study and control groups (p > 0.05). If a markedly weight gain was seen in the study group, a higher levels of serum leptin could be expected. Additionally, there was not a relationship between serum leptin and CBZ levels (r: 0.48; p > 0.05). Our preliminary findings showed that long-term use of CBZ did not cause markedly weight gain in childhood and serum leptin levels did not differ from the control subjects. We think that more extensive studies should be performed about this subject.
在本文中，我们研究了接受长期卡马西平（CBZ）治疗（平均3.4年）的儿童的血清瘦素水平，以确定血清瘦素水平与CBZ治疗之间是否存在关联。该研究包括14例诊断为癫痫并长期接受CBZ治疗的患者以及19名健康儿童。只有两名（14%）患者抱怨有暴饮暴食和体重增加的情况。我们发现研究组和对照组在年龄、性别、体重指数和血清瘦素水平方面没有任何显著差异（p>0.05）。如果在研究组中观察到明显的体重增加，那么可以预期血清瘦素水平会更高。此外，血清瘦素与CBZ水平之间没有关联（r：0.48；p>0.05）。我们的初步研究结果表明，长期使用CBZ不会导致儿童明显体重增加，且血清瘦素水平与对照组无差异。我们认为应该针对这个主题进行更广泛的研究。
