Department of Neurology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
Department of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
Acta Neurol Belg. 2021 Dec;121(6):1823-1830. doi: 10.1007/s13760-020-01552-7. Epub 2020 Nov 26.
Antiepileptic drugs may cause systemic and metabolic side effects. The aim of our study was to investigate the effects of valproic acid and carbamazepine monotherapy used in the treatment of epilepsy patients on serum adiponectin and carnitine levels. The study included 60 patients, of which 30 patients receiving valproic acid monotherapy and 30 patients receiving carbamazepine monotherapy, who were followed up by the epilepsy outpatient clinic with the diagnosis of idiopathic epilepsy, and 30 healthy volunteers. Patients, who used drugs for at least 6 months, were selected. Venous blood samples were collected from the patients and healthy volunteers after their consent was obtained. Serum carnitine and adiponectin levels in the collected samples were measured using the ELISA method. Serum carnitine levels were 5166.55 ng/ml (± 1954.92) in patients receiving carbamazepine, 4224.56 ng/ml (± 2055.54) in patients using valproic acid, and 5802.64 ng/ml (± 3422.57) in the control group. Serum adiponectin levels were 13,606.51 ng/ml (± 5915.92) in patients using carbamazepine, 11,986.58 ng/ml (± 5367.82) in patients receiving valproic acid, and 14,033.43 ng/ml (± 5646.34) in the control group. In both groups, both serum carnitine and serum adiponectin levels were lower than the control group. There was a negative but insignificant correlation between the duration and dose of carbamazepine and valproic acid drug use and serum adiponectin and carnitine levels. There is a need for more extensive studies with larger sample size to investigate the effect of antiepileptic drugs used on serum adiponectin and carnitine levels.
抗癫痫药物可能会引起全身和代谢方面的副作用。我们的研究旨在探讨丙戊酸和卡马西平单药治疗癫痫患者对血清脂联素和肉碱水平的影响。该研究纳入了 60 名患者，其中 30 名患者接受丙戊酸单药治疗，30 名患者接受卡马西平单药治疗，他们在癫痫门诊接受随访，诊断为特发性癫痫，还有 30 名健康志愿者。选择了使用药物至少 6 个月的患者。从患者和健康志愿者处采集静脉血样本，在获得他们的同意后进行。使用 ELISA 法测量收集样本中的血清肉碱和脂联素水平。接受卡马西平治疗的患者血清肉碱水平为 5166.55ng/ml（±1954.92），接受丙戊酸治疗的患者为 4224.56ng/ml（±2055.54），对照组为 5802.64ng/ml（±3422.57）。接受卡马西平治疗的患者血清脂联素水平为 13606.51ng/ml（±5915.92），接受丙戊酸治疗的患者为 11986.58ng/ml（±5367.82），对照组为 14033.43ng/ml（±5646.34）。在这两组中，血清肉碱和血清脂联素水平均低于对照组。卡马西平和丙戊酸药物使用的持续时间和剂量与血清脂联素和肉碱水平之间存在负相关，但无统计学意义。需要进行更大规模、样本量更大的研究来探讨抗癫痫药物对血清脂联素和肉碱水平的影响。
