Kumar Shaji, Witzig Thomas E, Greipp Philip R, Rajkumar S Vincent
Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Br J Haematol. 2003 Jul;122(2):272-4. doi: 10.1046/j.1365-2141.2003.04428.x.
Bone marrow (BM) angiogenesis is increased in multiple myeloma (MM) and has prognostic significance. The presence of circulating plasma cells (PCs) in MM is associated with a poorer prognosis. We examined BM biopsies obtained at diagnosis of MM for angiogenesis, and correlated the microvessel density (MVD) with the presence of circulating PCs. There was a positive correlation between the absolute number of circulating PCs and the mean MVD. This relationship was independent of the disease activity and of the PC burden in the marrow. The increased angiogenesis may promote plasma cell proliferation and enable PC migration into the circulation.
多发性骨髓瘤（MM）中骨髓（BM）血管生成增加，且具有预后意义。MM中循环浆细胞（PCs）的存在与较差的预后相关。我们检查了MM诊断时获取的骨髓活检组织的血管生成情况，并将微血管密度（MVD）与循环PCs的存在进行关联。循环PCs的绝对数量与平均MVD之间存在正相关。这种关系独立于疾病活动和骨髓中PC的负荷。血管生成增加可能促进浆细胞增殖，并使PC迁移到循环中。
