Mingers A M
Universitäts-Kinderklinik Würzburg, BRD.
Beitr Infusionsther. 1992;30:265-7.
During childhood preoperative coagulation diagnosis is performed to prove or to rule out an inborn coagulation disorder or an acquired von Willebrand disease. The coagulation system of the newborn differs considerably from that of the adults as well as the time in which the single parameters reach adult values. Reducing the coagulation screening to the determination of aPTT and Quick test neglects severe hemostaseological disorders easily, such as von Willebrand disease which is often observed in childhood and often combined with normal aPTT values. Sometimes children affected with hypertrophy of the adenoids have temporary aPTT prolongations combined with normal values for the other coagulation parameters possibly due to lupus inhibitors. When children with deficiencies of coagulation factors need high doses of coagulation concentrates, the number of laboratory controls may be reduced by determination of recovery and the half-life period some time before.
在儿童期，进行术前凝血诊断以证实或排除先天性凝血障碍或获得性血管性血友病。新生儿的凝血系统与成人有很大不同，而且各个参数达到成人值的时间也不同。将凝血筛查仅局限于活化部分凝血活酶时间（aPTT）测定和 Quick 试验，很容易忽略严重的止血学障碍，比如在儿童期经常见到且 aPTT 值常正常的血管性血友病。有时患腺样体肥大的儿童会出现 aPTT 暂时延长，而其他凝血参数值正常，这可能是由于狼疮抑制剂所致。当凝血因子缺乏的儿童需要高剂量凝血浓缩物时，可通过提前一段时间测定回收率和半衰期来减少实验室检查的次数。
