Mingers A M
Univ.-Kinderklinik Würzburg.
Infusionsther Transfusionsmed. 1992 Jun;19(3):105-9.
During childhood preoperative coagulation diagnosis is performed to prove or to rule out an inborn coagulation disorder or an acquired v. Willebrand disease. The coagulation system of the newborns differs considerably from that of the adults as well as the time in which the single parameters reach adult values. Reducing the coagulation screening to the determination of aPTT and Quicktest neglects severe hemostaseological disorders easily, e.g. v. Willebrand disease which often in childhood is to be observed and often combined with normal aPTT values. Probably sometimes children affected with hypertrophy of the adenoids have temporary aPTT prolongations combined with normal values for the other coagulation parameters possibly due to lupus inhibitors. When children with deficiencies of coagulation factors need high doses of coagulation concentrates the number of laboratory controls may be reduced by determination on recovery and half-life period some times before.
在儿童时期，进行术前凝血诊断是为了证实或排除先天性凝血障碍或获得性血管性血友病。新生儿的凝血系统与成年人有很大不同，而且各个参数达到成人值的时间也不同。将凝血筛查仅局限于活化部分凝血活酶时间（aPTT）和 Quicktest 的测定，很容易忽略严重的止血学障碍，例如血管性血友病，这种疾病在儿童期经常可见，且常常伴有正常的 aPTT 值。患有腺样体肥大的儿童有时可能会出现 aPTT 暂时延长，而其他凝血参数值正常，这可能是由于狼疮抑制剂所致。当凝血因子缺乏的儿童需要高剂量的凝血浓缩物时，有时可以通过提前测定回收率和半衰期来减少实验室检查的次数。
