Bonnert J, Kiefel V, Kroll H, Mueller-Eckhardt C
Institut für klinische Immunologie und Transfusionsmedizin, Justus-Liebig-Universität, Giessen, BRD.
Beitr Infusionsther. 1992;30:399-402.
Antibodies against platelet specific alloantigens cause neonatal alloimmune thrombocytopenia, posttransfusion purpura, and they are sometimes found in polytransfused patients. In the last few years, new alloantigens were discovered in addition to the Zw-, Bak-, and Ko-alloantigens. In order to obtain representative data for the frequency of all platelet alloantigens in the European population, we typed 400 blood donors of our institution. No significant differences between our findings and data already published were found for the antigens of the HPA-1, -2, -3, and -5 systems; however, no HPA-4b (Yuka)-positive and no Naka-negative individual was found among the 400 blood donors tested. The Siba and HPA-2b antigens proved to be identical. The 'low-frequency' alloantigen Sra was not identified among the 400 individuals tested.
针对血小板特异性同种抗原的抗体可导致新生儿同种免疫性血小板减少症、输血后紫癜，并且有时在多次输血的患者中也能发现此类抗体。在过去几年中，除了Zw-、Bak-和Ko-同种抗原外，还发现了新的同种抗原。为了获取欧洲人群中所有血小板同种抗原频率的代表性数据，我们对本机构的400名献血者进行了分型。对于HPA-1、-2、-3和-5系统的抗原，我们的研究结果与已发表的数据之间未发现显著差异；然而，在所检测的400名献血者中，未发现HPA-4b（Yuka）阳性个体，也未发现Naka阴性个体。结果证明Siba和HPA-2b抗原是相同的。在所检测的400名个体中未发现“低频”同种抗原Sra。
