Urwijitaroon Y, Barusrux S, Romphruk A, Puapairoj C
Blood Transfusion Centre, Faculty of Medicine, Khon Kaen University, Thailand.
Transfusion. 1995 Oct;35(10):868-70. doi: 10.1046/j.1537-2995.1995.351096026370.x.
Platelet transfusions have been widely used in Thailand, but little is known about the phenotyping of human platelet antigens.
Whole blood was collected from 483 blood donors for preparation of platelets. An improved mixed passive hemagglutination assay was used for this study.
Frequencies demonstrated were 100 percent for HPA-1a (PlA1), 15.94 percent for HPA-2b (Siba), 60.25 percent for HPA-3a (Baka), 98.76 percent for HPA-4a (Yukb), 1.86 percent for HPA-4b (Yuka), 5.38 percent for HPA-5b (Br(a)), and 97.72 percent for Naka.
HPA-1a was found in 100 percent of Thais, which is the same frequency as in other Asian populations but somewhat different from that in whites (97.9%). Therefore, HPA-1a will not cause neonatal alloimmune thrombocytopenia or post-transfusion purpura in Thais. According to the frequencies of HPA-2b, HPA-3a, HPA-4a, HPA-4b, HPA-5b, and Naka antigens, they may induce neonatal alloimmune thrombocytopenia, posttransfusion purpura, and platelet refractoriness in Thais.
血小板输注在泰国已被广泛使用，但关于人类血小板抗原的表型分析却知之甚少。
采集483名献血者的全血用于制备血小板。本研究采用改良的混合被动血凝试验。
检测到的频率为：HPA-1a（PlA1）为100%，HPA-2b（Siba）为15.94%，HPA-3a（Baka）为60.25%，HPA-4a（Yukb）为98.76%，HPA-4b（Yuka）为1.86%，HPA-5b（Br(a)）为5.38%，Naka为97.72%。
在100%的泰国人中发现了HPA-1a，这一频率与其他亚洲人群相同，但与白人（97.9%）略有不同。因此，HPA-1a不会在泰国人中引起新生儿同种免疫性血小板减少症或输血后紫癜。根据HPA-2b、HPA-3a、HPA-4a、HPA-4b、HPA-5b和Naka抗原的频率，它们可能会在泰国人中诱发新生儿同种免疫性血小板减少症、输血后紫癜和血小板输注无效。
