沙特阿拉伯成人霍奇金淋巴瘤的变化趋势。

The changing trends of adult Hodgkin's disease in Saudi Arabia.

作者信息

Al-Diab Abdulrahman I, Siddiqui Neelam, Sogiawalla Firoze F, Fawzy Essam M

机构信息

Department of Medicine, Division of Oncology, College of Medicine, King Khalid University Hospital, PO Box 2925, Riyadh 11461, Kingdom of Saudi Arabia.

出版信息

Saudi Med J. 2003 Jun;24(6):617-22.

PMID:12847590

Abstract

OBJECTIVE

Hodgkin's disease is one of the most common malignant lymphomas affecting the younger population. This disease has diversified pathologies and clinical stages that necessitate a well optimized clinical management. Regular updating of epidemiological behavior of Hodgkin's disease is obvious from various parts of the world; however, studies from the Kingdom of Saudi Arabia (KSA) in this field are scanty and more than a decade old. The aim of this study was to investigate the current trends in presentation and distribution of Hodgkin's disease with special reference to gender, age, histopathological subtypes, and clinical stages of this disease in Saudi patients.

METHODS

A total of 142 Hodgkin's disease patients attending 2 referral hospitals (King Khalid University Hospital and Security Forces Hospital) in Riyadh, KSA, were included in this study. The records from the questionnaires were analyzed retrospectively for determining the trends of Hodgkin's disease in Saudi adults, over a period of 15 years (1985-2000).

RESULTS

There were 86 males and 56 females, with a male to female ratio of 1.53:1. The mean age of the patients was 28.63 years, while most of the patients were <40 years (80.3%). Nodular sclerosis was the most frequent pathology. Presence of B symptoms had a significant correlation with histology type as well as clinical stage of Hodgkin's disease. Time course analysis showed the increasing trend of Hodgkin's disease frequency, especially in younger adults. The rate of nodular sclerosis continued to increase during the entire course of study whereas the frequency of other histology types showed a decreasing trend during 1992-2000.

CONCLUSION

To the author's knowledge, this is the largest case series of adult Hodgkin's disease from KSA. The results of this study revealed a different pattern of Hodgkin's disease as compared to earlier studies reported from this region. These findings provide valuable insights in the understanding of current epidemiological features of Hodgkin's disease in KSA.

摘要

目的

霍奇金淋巴瘤是影响年轻人群的最常见恶性淋巴瘤之一。该病具有多种病理类型和临床分期，因此需要优化临床管理。世界各地对霍奇金淋巴瘤的流行病学行为进行定期更新很有必要；然而，沙特阿拉伯王国（KSA）在该领域的研究较少，且距今已有十多年历史。本研究的目的是调查沙特患者中霍奇金淋巴瘤的临床表现和分布的当前趋势，特别参考该疾病的性别、年龄、组织病理学亚型和临床分期。

方法

本研究纳入了沙特阿拉伯利雅得市2家转诊医院（哈立德国王大学医院和安全部队医院）的142例霍奇金淋巴瘤患者。对问卷记录进行回顾性分析，以确定沙特成年人在15年期间（1985 - 2000年）霍奇金淋巴瘤的发病趋势。

结果

男性86例，女性56例，男女比例为1.53:1。患者的平均年龄为28.63岁，大多数患者年龄小于40岁（80.3%）。结节硬化是最常见的病理类型。B症状的出现与霍奇金淋巴瘤的组织学类型以及临床分期显著相关。时间进程分析显示霍奇金淋巴瘤的发病率呈上升趋势，尤其是在年轻成年人中。在整个研究过程中，结节硬化的发病率持续上升，而其他组织学类型的发病率在1992 - 2000年呈下降趋势。