麻风病的逆转反应。

Reversal reaction to Hansen's disease.

作者信息

Jih Ming H, Kimyai-Asadi Arash, Levis William R

机构信息

Department of Dermatology, New York University School of Medicine, 401 East 34th Street, S-6N, New York, NY 10016, USA.

出版信息

J Drugs Dermatol. 2002 Jul;1(1):70-1.

PMID:12847760

Abstract

A 25-year-old man with a history of mid-borderline (BB) Hansen's disease developing a reversal reaction after starting dapsone and rifampin therapy is presented. His clinical features included erythematous, edematous plaques and peripheral neuropathy. Reversal reactions are caused immunologically by enhanced cell-mediated (Th-1) immunity to Mycobacterium leprae, resulting in inflammation of infected tissues, such as skin and nerves. Acute neuritis can lead to permanent nerve damage and necessitate prompt treatment with prednisone and/or clofazamine.

摘要

本文报告了一名25岁男性，有中度边缘型（BB）汉森病病史，在开始使用氨苯砜和利福平治疗后发生了逆转反应。他的临床特征包括红斑、水肿性斑块和周围神经病变。逆转反应是由针对麻风杆菌的细胞介导（Th-1）免疫增强在免疫上引起的，导致受感染组织（如皮肤和神经）发生炎症。急性神经炎可导致永久性神经损伤，需要立即用泼尼松和/或氯法齐明进行治疗。