Kleinrok Z, Jagiełł-Wójtowicz E, Nowicky J W, Chodkowska A, Feldo M, Matuszek B
Department of Pharmacology, Medical Academy, Lublin, Poland.
Drugs Exp Clin Res. 1992;18 Suppl:93-6.
Some pharmacological properties of Ukrain administered intraperitoneally (i.p.) once daily for three months in mice and rats of both sexes were studied. A three month treatment with Ukrain significantly depressed the spontaneous locomotor activity and did not affect the motor coordination of mice and rats of both sexes. Ukrain did not affect the body weight gain as well as the mass of internal organs; the exception was an increase in the mass of the spleen in rats. Biochemical studies indicated that a three month treatment with Ukrain depressed the whole brain dopamine (DA) concentrations and did not affect the noradrenaline (NA) concentrations. Long-term administration of Ukrain showed no characteristic changes in the concentrations of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the whole brain. The observed changes after three months' treatment with Ukrain are similar in mice and rats of both sexes.
研究了乌头碱对雌雄小鼠和大鼠每日腹腔注射一次，连续三个月后的一些药理学特性。连续三个月用乌头碱治疗可显著降低雌雄小鼠和大鼠的自发运动活性，但不影响其运动协调性。乌头碱不影响体重增加以及内脏器官质量；大鼠脾脏质量增加是个例外。生化研究表明，连续三个月用乌头碱治疗可降低全脑多巴胺（DA）浓度，但不影响去甲肾上腺素（NA）浓度。长期给予乌头碱后，全脑中5-羟色胺（5-HT）和5-羟吲哚乙酸（5-HIAA）浓度无特征性变化。连续三个月用乌头碱治疗后观察到的变化在雌雄小鼠和大鼠中相似。
