Jagiełło-Wójtowicz E, Kleinrok Z, Nowicky J W, Matuszek B, Baran E, Surmaczynska B
Department of Pharmacology, Medical Academy, Lublin, Poland.
Drugs Exp Clin Res. 1992;18 Suppl:89-91.
The effect of single and prolonged administration of Ukrain on the serum prolactin concentrations in rats of both sexes was investigated. One hour after intraperitoneal (i.p.) administration of Ukrain in rats, in doses of 7, 14 and 28 mg/kg, the drug did not affect their serum prolactin concentration. Only in a dose of 28 mg/kg did this drug decrease serum prolactin in a group of female rats. Repeated i.p. treatment (once daily for three months) with 7, 14 and 28 mg/kg of Ukrain significantly increased the serum prolactin concentration in rats of both sexes. The most marked effect was observed in the group of female rats.
研究了单次及长期给予乌头碱对雌雄大鼠血清催乳素浓度的影响。给大鼠腹腔注射7、14和28mg/kg剂量的乌头碱1小时后，该药物对其血清催乳素浓度无影响。仅在28mg/kg剂量时，该药物使一组雌性大鼠的血清催乳素降低。用7、14和28mg/kg的乌头碱重复腹腔注射治疗（每日一次，共三个月）显著提高了雌雄大鼠的血清催乳素浓度。在雌性大鼠组中观察到最明显的效果。
