Carcillo Joseph A
Division of Critical Care Medicine, Children's Hospital of Pittsburgh, 3705 5th Avenue, Pittsburgh, PA 15123, USA.
Crit Care Clin. 2003 Jul;19(3):413-40, viii. doi: 10.1016/s0749-0704(03)00013-7.
In the last 5 years, the understanding of the epidemiology and pathogenesis of pediatric sepsis, septic shock, and multiple organ failure has expanded greatly. There has also been a substantial increase in the number of successful randomized trials in which success has been measured as reduction in mortality in adults, children, and newborns. This article discusses these advances, updating the 1997 article on septic shock written by the author and by Dr. Robert E. Cunnion and following the format of the 1997 article.
在过去5年里，对儿童脓毒症、脓毒性休克和多器官功能衰竭的流行病学及发病机制的认识有了极大拓展。成功的随机试验数量也大幅增加，这些试验的成功是以降低成人、儿童及新生儿的死亡率来衡量的。本文将讨论这些进展，采用1997年作者与罗伯特·E·坎尼恩博士撰写的关于脓毒性休克的文章的格式，对其进行更新。
