Rózalska M, Mikucki J
Department of Pharmaceutical Microbiology, Medical University, Lódz, Poland.
Acta Microbiol Pol. 1992;41(3-4):145-50.
The regulation mechanism of production of staphylococcal L-asparaginase was investigated. The role of cAMP in regulation of its synthesis was confirmed. Production of L-asparaginase from S. aureus NCTC 4135 was inhibited by all carbon sources, mono- and disaccharides added to the growth medium. The strongest inhibition was caused by saccharose and maltose, whereas weaker by galactose, lactose, mannitol and mannose. It was found that exogenous cAMP in the presence of carbon sources stimulated synthesis of the investigated enzyme.
对葡萄球菌L-天冬酰胺酶的产生调节机制进行了研究。证实了环磷酸腺苷（cAMP）在其合成调节中的作用。添加到生长培养基中的所有碳源、单糖和双糖均抑制金黄色葡萄球菌NCTC 4135产生L-天冬酰胺酶。蔗糖和麦芽糖引起的抑制作用最强，而半乳糖、乳糖、甘露醇和甘露糖引起的抑制作用较弱。研究发现，在有碳源存在的情况下，外源性cAMP会刺激所研究酶的合成。
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