Foxman Betsy, Brown Patricia
Department of Epidemiology, Center for Molecular and Clinical Epidemiology of Infectious Diseases, University of Michigan School of Public Health, 109 Observatory Street, Ann Arbor, MI 48109-2029, USA.
Infect Dis Clin North Am. 2003 Jun;17(2):227-41. doi: 10.1016/s0891-5520(03)00005-9.
Uropathogenic E. coli have special features that allow them to take advantage of the bladder environment. There UPEC can grow to substantial numbers in pure culture that are shed frequently into the environment and have a high probability of transmission to other hosts. A better understanding of the transmission system and the host and bacterial factors influencing transmission is essential for the identification of effective prevention strategies. Although the risk of severe morbidity among otherwise healthy populations is low, the incidence is high. Further, the potential impact of antibiotic treatment on the emergence of increasingly antibiotic-resistant UPEC (the resistant mechanisms that may be transmitted to other bowel inhabitants) is high. The benefits of successfully preventing UTI are substantial.
尿路致病性大肠杆菌具有一些特殊特征，使其能够利用膀胱环境。在那里，尿路致病性大肠杆菌在纯培养物中可大量生长，这些细菌经常排放到环境中，并很有可能传播给其他宿主。更好地了解传播系统以及影响传播的宿主和细菌因素，对于确定有效的预防策略至关重要。虽然在其他方面健康的人群中发生严重发病的风险较低，但发病率却很高。此外，抗生素治疗对越来越具抗生素抗性的尿路致病性大肠杆菌（其抗性机制可能会传播给其他肠道细菌）出现的潜在影响很大。成功预防尿路感染的益处是巨大的。
