Kim Dong Ho, Subhadra Bindu, Kang Hee Young, Woo Kyungho, Kim Jaeseok, Son Yeo-Jin, Sohn Kyung Mok, Kim Hwa-Jung, Han Kyudong, Oh Man Hwan, Choi Chul Hee
Department of Microbiology and Medical Science, Chungnam National University School of Medicine, 266 Munwha-ro, Jung-gu, Daejeon, 35015, Republic of Korea.
Bacterial Disease Division, Animal and Plant Quarantine Agency, Gimcheon-si, Gyeonsangbuk-do, Republic of Korea.
Genes Genomics. 2018 Jun;40(6):625-634. doi: 10.1007/s13258-018-0664-6. Epub 2018 Feb 14.
Urinary tract infections (UTIs) are one of the most common types of bacterial infection in humans in various parts of the world and are caused mainly by uropathogenic Escherichia coli (UPEC). A total of 58 UPEC isolates from urine were characterized by serotyping and pulsed-field gel electrophoresis (PFGE). The majority of the UPEC strains belonged to serogroups O2 and O6. The UPEC strains were grouped under different pulsotypes and majority of them belonged to serogroups O2 and O6. Among the 14 virulence factors considered, 13 were present in various serogroups. The virulence genes fimH and sfa were present in all the isolates while none of the isolates carried lt-1. The strains exhibited 36 different virulence patterns, of which 11, referred to as UP (UPEC pattern) 1 to UP 11 were most common. Antibiotic resistance profiling of the UPEC isolates revealed that the serogroups O2 and O6 contain the highest number of resistant strains. The data from the current study depicting the distribution of UPEC strains among various serogroups and pulsotypes, and the occurrence of virulence genes and antibiotics resistance offer useful information on the epidemiological features of UPEC in Korea for the enhanced surveillance of potential emergence of UPEC.
尿路感染（UTIs）是世界各地区人类最常见的细菌感染类型之一，主要由尿路致病性大肠杆菌（UPEC）引起。对从尿液中分离出的58株UPEC菌株进行了血清分型和脉冲场凝胶电泳（PFGE）鉴定。大多数UPEC菌株属于O2和O6血清群。UPEC菌株被分为不同的脉冲型，其中大多数属于O2和O6血清群。在考虑的14种毒力因子中，13种存在于不同血清群中。所有分离株均存在毒力基因fimH和sfa，而无一分离株携带lt-1。这些菌株表现出36种不同的毒力模式，其中11种，称为UP（UPEC模式）1至UP 11最为常见。UPEC分离株的抗生素耐药性分析表明，O2和O6血清群中的耐药菌株数量最多。本研究的数据描述了UPEC菌株在不同血清群和脉冲型中的分布，以及毒力基因的存在情况和抗生素耐药性，为加强对韩国UPEC潜在出现情况的监测提供了有关UPEC流行病学特征的有用信息。
