Kanai K, Akksilp S, Naigowit P, Chaowagul V, Kurata T
National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
Jpn J Med Sci Biol. 1992 Oct-Dec;45(5-6):231-45. doi: 10.7883/yoken1952.45.231.
The serosensitivity to Pseudomonas pseudomallei antigen in pulmonary tuberculous patients was surveyed in Ubon Ratchathani Province, a melioidosis-endemic and tuberculosis-prevalent area in Thailand. Indirect hemagglutination assay (IHA) and indirect immunofluorescent assay (IFA) for IgM and IgG were employed for the measurement of antibody levels, with cut-off points set at 1:160, 1:8, and 1:32, respectively. Retrospective protocol survey of clinical data was also conducted. From these studies, however, no evidence was obtained to show that tuberculous patients have a disposition to acquire double-infected with P. pseudomallei and to develop melioidosis. The serosensitivity was never higher than that of the general population of the province as represented by healthy blood donors, nor related with the clinical severeness. Tuberculosis and melioidosis appear to be mutually independent diseases without showing interrelated prevalence in the endemic area.
在泰国乌汶叻差他尼省（一个类鼻疽病流行且结核病高发的地区），对肺结核患者针对类鼻疽假单胞菌抗原的血清敏感性进行了调查。采用间接血凝试验（IHA）以及针对IgM和IgG的间接免疫荧光试验（IFA）来测定抗体水平，其截断点分别设定为1:160、1:8和1:32。还对临床数据进行了回顾性方案调查。然而，从这些研究中，未获得证据表明结核患者有倾向于同时感染类鼻疽假单胞菌并发展为类鼻疽病。血清敏感性从未高于以健康献血者为代表的该省普通人群，也与临床严重程度无关。结核病和类鼻疽病似乎是相互独立的疾病，在该流行地区未显示出相关的患病率。
