[Enhancing the reparative potentials of the cellular structures in the hypothalamus by the preliminary adaptation of animals to hypoxia and stress].

Effects of preliminary adaptation of rats to hypoxic hypoxia and short-term stress environments on the dynamics of the repair changes of RNA and proteins in the cellular structures of supraoptic (SON) and paraventricular (PVN) nuclei of hypothalamus are studied. Adaptation to hypoxia and short-term stresses is found to increase the potential of protein-synthetizing system of neuro- and gliocytes of SON and PVN. It prevented a marked decrease in the RNA and proteins contents during a post-stress period and increased an intensity of the repair processes in the nuclei being tested. Experimental findings are indicative of a heterochronic pattern of repair processes in hypothalamic neurosecretory structures which to a great extent can be related with their potentials to rearrange the intracellular metabolism for maximum functional maintenance during stresses.