[The protective action of different types and regimens of adaptation to hypoxia on the development of stress-induced lesions in KM strain (Krushinskiĭ-Molodkina) rats].

The effect of preliminary adaptation to hypoxia on the development of stress-induced lesions was studied on the model of acoustic stress in the Krushinskiĭ-Molodkina line rats genetically predisposed to audiogenic seizures. At different regimens of adaptation to hypoxia (long- and short-term, continuous, intermittent), a decrease of the death rate, severity of motor disorders, incidence and degree of intracranial hemorrhages occurred. Only when using a hypoxic gas mixture, a reduction of excitability of the c.n.s. was revealed: the latency increased whereas the intensity of the seizure decreased. Two-hour normobaric hypoxic stimulation prevented an increase in the lipid peroxidation products and contributed to a rise of cyclic nucleotides concentration in the brain hemispheres of the KM line rats exposed to acoustic stress.