Wykes Michelle
Queensland Institute of Medical Research, The Bancroft Centre, Herston Road, Brisbane 4006, Australia.
Immunol Cell Biol. 2003 Aug;81(4):328-31. doi: 10.1046/j.1440-1711.2003.01171.x.
The CD40-CD40 ligand (CD40L) interaction is one of the most important receptor-ligand interactions that occurs during a T dependent immune response. However, while CD40L is expressed on a range of cell types including activated T cells and B cells, dendritic cells granulocytes, macrophages and platelets, only CD40L on T cells is considered by most immunologists when planning experiments or analysing data. The current theory professes that T cells expressing CD40L can provide signals to B cells that induce proliferation, immunoglobulin class switching, antibody secretion, rescue from apoptosis at different times during the life of a B cell and also has a role in the development of germinal centres and the survival of memory B cells. However, the whole story is more complex than presently understood as human and mouse B cells express CD40L on their surface following activation and can release a soluble form of the ligand. This paper hypothesizes how CD40L on B cells may regulate antibody responses and the development of germinal centres.
CD40与CD40配体（CD40L）的相互作用是T细胞依赖性免疫反应过程中最重要的受体-配体相互作用之一。然而，虽然CD40L在包括活化T细胞、B细胞、树突状细胞、粒细胞、巨噬细胞和血小板在内的多种细胞类型上表达，但大多数免疫学家在设计实验或分析数据时，仅考虑T细胞上的CD40L。当前理论认为，表达CD40L的T细胞可向B细胞提供信号，诱导B细胞增殖、免疫球蛋白类别转换、抗体分泌，在B细胞生命周期的不同时间使其免于凋亡，并且在生发中心的发育和记忆B细胞的存活中也发挥作用。然而，实际情况比目前所理解的更为复杂，因为人和小鼠的B细胞在活化后会在其表面表达CD40L，并能释放可溶性形式的配体。本文推测B细胞上的CD40L可能如何调节抗体反应和生发中心的发育。
