锥虫中的程序性细胞死亡：它是适者生存的一种利他机制吗？
Programmed cell death in trypanosomatids: is it an altruistic mechanism for survival of the fittest?
作者信息
Debrabant Alain, Nakhasi Hira
机构信息
Laboratory of Bacterial, Parasitic and Unconventional Agents,Division of Emerging and Transfusion Transmitted Diseases, OBRR/CBER/FDA, Bldg,29, Rm,222, HFM-310, 8800 Rockville Pike, Bethesda, MD 20892, USA.
出版信息
Kinetoplastid Biol Dis. 2003 Jun 25;2(1):7. doi: 10.1186/1475-9292-2-7.
The protozoan parasites Leishmania, Trypanosoma cruzi and Trypanosoma brucei show multiple features consistent with a form of programmed cell death (PCD). Despite some similarities with apoptosis of mammalian cells, PCD in trypanosomatid protozoans appears to be significantly different. In these unicellular organisms, PCD could represent an altruistic mechanism for the selection of cells, from the parasite population, that are fit to be transmitted to the next host. Alternatively, PCD could help in controlling the population of parasites in the host, thereby increasing host survival and favoring parasite transmission, as proposed by Seed and Wenk. Therefore, PCD in trypanosomatid parasites may represent a pathway involved both in survival and propagation of the species.
原生动物寄生虫利什曼原虫、克氏锥虫和布氏锥虫表现出多种与程序性细胞死亡（PCD）形式一致的特征。尽管与哺乳动物细胞凋亡有一些相似之处，但锥虫原生动物中的PCD似乎有显著差异。在这些单细胞生物中，PCD可能代表一种利他机制，用于从寄生虫群体中选择适合传播给下一个宿主的细胞。或者，正如Seed和Wenk所提出的，PCD可能有助于控制宿主体内的寄生虫数量，从而提高宿主的存活率并有利于寄生虫传播。因此，锥虫寄生虫中的PCD可能代表了一条与该物种的生存和繁殖都有关的途径。
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