精氨酸的修饰及其在自身免疫中的作用。
Modifications of arginines and their role in autoimmunity.
作者信息
van Boekel M A M, van Venrooij W J
机构信息
Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands.
出版信息
Autoimmun Rev. 2003 Mar;2(2):57-62. doi: 10.1016/s1568-9972(02)00128-3.
Posttranslational modifications of proteins often perform a key role in the biological functioning of proteins. Some of these modifications also change the immunogenicity of proteins and peptides and create 'self'-antigens which might induce autoimmune responses. In particular modifications of arginines within a defined protein context can lead to a specific B-cell immune response. This review discusses the generation of such modifications and their relevance for autoimmunity.
蛋白质的翻译后修饰通常在蛋白质的生物学功能中起关键作用。其中一些修饰还会改变蛋白质和肽的免疫原性，并产生可能诱导自身免疫反应的“自身”抗原。特别是在特定蛋白质环境中精氨酸的修饰可导致特定的B细胞免疫反应。本综述讨论了此类修饰的产生及其与自身免疫的相关性。
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