Anderton Stephen M
University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, Kings Buildings, West Mains Road, Edinburgh, EH9 3JT, UK.
Curr Opin Immunol. 2004 Dec;16(6):753-8. doi: 10.1016/j.coi.2004.09.001.
Alterations in amino acid sequence can generate neo-epitopes from self proteins, causing autoaggressive immune attack. There is a range of possible post-translational modifications (PTMs) of mammalian proteins that can allow immune recognition of neo-self epitopes. These effects can vary from overt increase in affinity of MHC or T-cell receptor binding, to more subtle effects on the activity of proteolytic enzymes involved in antigen processing. Furthermore, intriguing insights into how the complex interactions between inflammation, enzyme activity and protein modification can direct self recognition are beginning to be unearthed.
氨基酸序列的改变可从自身蛋白质产生新表位，引发自身攻击性免疫攻击。哺乳动物蛋白质存在一系列可能的翻译后修饰（PTM），这些修饰可使新的自身表位被免疫识别。这些效应的范围从MHC或T细胞受体结合亲和力的明显增加，到对抗抗原加工过程中蛋白水解酶活性的更微妙影响。此外，关于炎症、酶活性和蛋白质修饰之间复杂相互作用如何指导自身识别的有趣见解正开始被揭示出来。
