Filaci Gilberto, Suciu-Foca Nicole
Department of Internal Medicine, University of Genoa, Viale Benedetto XV n.6, 16132-Genova, Italy.
Autoimmun Rev. 2002 Oct;1(5):279-83. doi: 10.1016/s1568-9972(02)00065-4.
The CD8+ T suppressor lymphocytes identified in humans belong to three different subpopulations. All of them inhibit the proliferation of antigen-specific T cells. The type 1 and type 2 of CD8+ T suppressor cells are characterized by the CD8+CD28- phenotype, while no detailed data are available at the moment on the phenotype of the type 3 of CD8+ T suppressor cells. The type 1 of CD8+ suppressor T lymphocytes acts by inducing alteration of expression of co-stimulatory molecules on dendritic cells. A cell-to-cell contact is required to mediate this effect. The type 2 of CD8+ T suppressor cells induces inhibition via cytokine secretion (IFNgamma, IL6) and do not need to interact directly with antigen presenting cells. The type 3 of CD8+ T suppressor cells mediates its function through the secretion of IL10. The complexity and multiplicity of CD8+ T suppressor cell subsets suggests that these cells may have an important role in the regulation of the immune homeostasis, acting together with the CD4+ T regulatory cell subpopulations. The specificity of the functions of each of these suppressor/regulatory subsets in the immune network requires to be clarified to better understand the immune system, its functions and the possibilities to modulate its activities in the course of immune-mediated diseases.
在人类中鉴定出的CD8 + T抑制淋巴细胞属于三个不同的亚群。它们都抑制抗原特异性T细胞的增殖。CD8 + T抑制细胞的1型和2型以CD8 + CD28-表型为特征，而目前关于CD8 + T抑制细胞3型的表型尚无详细数据。CD8 +抑制性T淋巴细胞1型通过诱导树突状细胞上共刺激分子表达的改变来发挥作用。介导这种效应需要细胞间接触。CD8 + T抑制细胞2型通过细胞因子分泌（IFNγ、IL6）诱导抑制，并且不需要与抗原呈递细胞直接相互作用。CD8 + T抑制细胞3型通过分泌IL10来介导其功能。CD8 + T抑制细胞亚群的复杂性和多样性表明，这些细胞可能在免疫稳态的调节中发挥重要作用，与CD4 + T调节细胞亚群共同发挥作用。这些抑制/调节亚群中每一个在免疫网络中的功能特异性需要阐明，以便更好地理解免疫系统、其功能以及在免疫介导疾病过程中调节其活动的可能性。
