Chasle Sharon, How Christine C
Marie Curie Ward, The Cancer Centre, Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, UK.
Eur J Oncol Nurs. 2003 Jun;7(2):91-8. doi: 10.1016/s1462-3889(02)00081-9.
Nurses are now primarily responsible for the provision of patient information, and the administration of an escalating number of cytotoxic agents. This paper aims to provide nurses with key information concerning the adverse effects of cytotoxic chemotherapy on the reproductive system of women of childbearing age. The provision of information on gonadal function and fertility is vital, particularly with the increase in the survival of women treated for cancer, and the trend towards women starting a family later in life. Gonadal toxicity of the various cytotoxic agents, disruption of the menstrual cycle, premature menopause, avoidance of pregnancy, chemotherapy in pregnancy, and fertility prospects post-chemotherapy are addressed in this paper.
护士现在主要负责提供患者信息，并管理数量不断增加的细胞毒性药物。本文旨在为护士提供有关细胞毒性化疗对育龄妇女生殖系统不良影响的关键信息。提供有关性腺功能和生育能力的信息至关重要，特别是随着癌症治疗后女性生存率的提高，以及女性晚育的趋势。本文讨论了各种细胞毒性药物的性腺毒性、月经周期紊乱、过早绝经、避免怀孕、孕期化疗以及化疗后的生育前景。
