Brandling-Bennett Erica M, White Desireé A, Armstrong Melissa M, Christ Shawn E, DeBaun Michael
Department of Psychology, Washington University, St. Louis, MO 63130, USA.
Dev Neuropsychol. 2003;24(1):423-34. doi: 10.1207/S15326942DN2401_01.
Frontal brain regions are thought to mediate strategic processes that facilitate memory. We hypothesized that children with frontal cerebral infarcts related to sickle cell disease (SCD) would exhibit impairments in long-term and working memory as a result of disruptions in strategic processing. Word-list learning and digit span tasks were used to assess verbal memory and strategic processing in 21 children with SCD without infarcts (controls) and in 10 children with SCD with frontal infarcts. On the word-list learning task, children with frontal infarcts performed more poorly in terms of learning and free recall, although recognition and cued recall were adequate; this pattern suggested intact encoding and storage with impaired retrieval. Children with frontal infarcts performed more poorly on backward digit span, although forward digit span was adequate; this pattern suggested intact maintenance with impaired manipulation of information in working memory. Overall, these findings support the notion that disruptions in strategic processing contribute to memory impairments in children with frontal infarcts.
额叶脑区被认为介导有助于记忆的策略性过程。我们假设，与镰状细胞病（SCD）相关的额叶脑梗死患儿会因策略性加工中断而在长期记忆和工作记忆方面表现出损伤。使用单词列表学习和数字广度任务来评估21名无梗死的SCD患儿（对照组）和10名有额叶梗死的SCD患儿的言语记忆和策略性加工。在单词列表学习任务中，有额叶梗死的患儿在学习和自由回忆方面表现更差，尽管识别和线索回忆正常；这种模式表明编码和存储完好，但提取受损。有额叶梗死的患儿在倒背数字广度任务中表现更差，尽管顺背数字广度正常；这种模式表明工作记忆中的信息维持完好，但信息操作受损。总体而言，这些发现支持这样一种观点，即策略性加工中断会导致有额叶梗死的患儿出现记忆损伤。
