镰状细胞病的神经认知变化：全面综述
Neurocognitive Changes in Sickle Cell Disease: A Comprehensive Review.
作者信息
Sahu Tarun, Pande Babita, Sinha Meenakshi, Sinha Ramanjan, Verma Henu Kumar
机构信息
Department of Physiology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.
Department of Immunopathology, Institute of lungs Biology and Disease, Comprehensive Pneumology Center, Helmholtz Zentrum, Neuherberg, Munich, Germany.
出版信息
Ann Neurosci. 2022 Oct;29(4):255-268. doi: 10.1177/09727531221108871. Epub 2022 Jul 10.
BACKGROUND
Sickle cell disease (SCD) is a type of hemoglobinopathy characterized by abnormal hemoglobin molecules, which includes numerous acute and chronic complications. Ischemic stroke, silent cerebral infarction, headache, and neurocognitive impairment are the most common neurological complications associated with SCD.
SUMMARY
Acute anemia because of SCD can cause cognitive impairments because of cerebral hypoxia. Cognitive abnormalities in SCD manifest in various aspects such as working memory, verbal learning, executive functions, and attention. These neurocognitive impairments have been associated with poor functional results, such as transitioning from juvenile to adult care, adherence to medications, and unemployment.
KEY MESSAGE
In this review, we focus on neurocognitive aspects of SCD patients based on different imaging techniques, psychological batteries, associated neuromarkers, and interventions for managing of cognitive deficiencies..
背景
镰状细胞病（SCD）是一种血红蛋白病，其特征是血红蛋白分子异常，包括许多急性和慢性并发症。缺血性中风、无症状脑梗死、头痛和神经认知障碍是与SCD相关的最常见神经并发症。
总结
SCD所致的急性贫血可因脑缺氧导致认知障碍。SCD中的认知异常表现在工作记忆、言语学习、执行功能和注意力等各个方面。这些神经认知障碍与不良功能结果相关，如从青少年护理过渡到成人护理、药物依从性和失业。
关键信息
在本综述中，我们基于不同的成像技术、心理测试、相关神经标志物以及认知缺陷管理干预措施，重点关注SCD患者的神经认知方面。
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