肺炎球菌和A组链球菌中的四环素耐药性。抗生素耐药性特设研究小组的报告。
Tetracycline resistance in pneumococci and group A streptococci. Report of an ad-hoc study group on antibiotic resistance.
出版信息
Br Med J. 1977 Jan 15;1(6054):131-3. doi: 10.1136/bmj.1.6054.131.
In a nationwide survey in the spring of 1975 into the prevalence of tetracycline resistance among pneumoccoci and group A streptococci isolates, 21 laboratories reported the sensitivity of isolates and details of the patients. Altogether 13% of the 1528 pneumococci isolated were resistant to tetracycline, but there were wide geographical variations. Thirty-six per cent of the 1515 streptococci isolated were resistant, and again there was considerable geographical variation. A high level of resistance in one organism did not correlate with a high level in the other. For both organisms resistance was commoner among inpatients and those aged 50 or over. Tetracycline should probably not be the drug of choice in penicillin-sensitive patients with group A streptococcal infections, but geographical variations were so wide that decisions on treatment are best made on the basis of local survey data.
1975年春季，在一项针对全国范围内肺炎球菌和A组链球菌分离株中四环素耐药性流行情况的调查中，21个实验室报告了分离株的敏感性及患者的详细情况。总共1528株分离出的肺炎球菌中，有13%对四环素耐药，但存在广泛的地域差异。1515株分离出的链球菌中，有36%耐药，同样存在相当大的地域差异。一种微生物的高耐药水平与另一种微生物的高耐药水平并无关联。对于这两种微生物，耐药性在住院患者以及50岁及以上人群中更为常见。对于对青霉素敏感的A组链球菌感染患者，四环素可能不应作为首选药物，但地域差异如此之大，治疗决策最好基于当地的调查数据来做出。
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