Avetisian E A, Adamian F A, Petrosian A A
Orbeli Institute of Physiology, Armenian Acad. Sci., 375028, Yerevan, 22 Br. Orbeli St., Republic of Armenia.
Ross Fiziol Zh Im I M Sechenova. 2002 Dec;88(12):1512-20.
The descending influences of the septal nuclei (lateral nucleus--LSN and bed nucleus stria terminalis--BNST) on activity of viscero-sensory neurons of the nucleus of tractus solitarius (NTS) identified by stimulation of cervical part of the n. vagus were investigated in the cat anaesthetised by chloraloze-nembutal combination. It was found that out of 70 units recorded in the NTS area 50 were identified as those of primary and secondary input vagal neurons. Influence of single, paired and frequency stimulation on the septal structures was studied on these neurons. It was revealed that 30% (15 un) reacted by phase-specific response to the single stimulation of the septal nuclei. The latent period of initial excitation was in the range 5-25 ms. During the paired stimulation these neurons were not able to react to the second stimulus for the equal 10-300 ms. It was revealed that 34% (17 un) of the identified vagal neurons reacted by a tonic change of their spontaneous activity. The increase of frequency stimulation to 20 Hz evoked different changes of the rhythmical activity of the vagal neurons (increase, diminishing or inhibition). The study of interaction between central and peripheral signals in the solitary neurons induced blocking influence of descending septal discharge on the vagal test response. It is possible that the septal downward impulses reach the vago-sensitive solitary neurons indirectly through other structures of the limbic brain (amygdala, hypothalamus) and participate in modulation of the spontaneous activity of these neurons.
在氯醛糖-戊巴比妥钠联合麻醉的猫身上，研究了隔核（外侧核——LSN和终纹床核——BNST）对经刺激迷走神经颈部而鉴定出的孤束核（NTS）内脏感觉神经元活动的下行影响。发现在NTS区域记录的70个单位中，有50个被鉴定为初级和次级迷走神经输入神经元。对这些神经元研究了单次、配对和频率刺激对隔区结构的影响。结果显示，30%（15个单位）的神经元对隔核的单次刺激呈现相位特异性反应。初始兴奋的潜伏期在5 - 25毫秒范围内。在配对刺激期间，这些神经元在10 - 300毫秒的相等时间内无法对第二个刺激做出反应。结果显示，34%（17个单位）的已鉴定迷走神经神经元通过其自发活动的紧张性变化做出反应。将频率刺激增加到20赫兹会引起迷走神经神经元节律性活动的不同变化（增加、减弱或抑制）。对孤束核神经元中中枢和外周信号之间相互作用的研究揭示了隔区下行放电对迷走神经测试反应的阻断影响。隔区向下的冲动可能通过边缘脑的其他结构（杏仁核、下丘脑）间接到达对迷走神经敏感的孤束核神经元，并参与这些神经元自发活动的调制。
