Avetisyan E A, Adamyan F A, Petrosyan A A
Laboratory for Autonomic Nervous System Physiology, L. A. Orbeli Institute of Physiology, 22 Orbeli Street, National Academy of Sciences, 375028 Erevan, Armenia.
Neurosci Behav Physiol. 2004 Jun;34(5):473-8. doi: 10.1023/b:neab.0000022632.05792.e4.
Studies on cats anesthetized with a mixture of Nembutal and chloralose were performed to study the descending influences of single, paired, and frequent stimulation of the lateral septal nucleus (LSN) and bed nucleus of the stria terminalis (BNST) on the activity of viscerosensory neurons in the solitary tract nucleus, identified by stimulation of the cervical part of the vagus nerve. Of 70 units recorded in the solitary tract nucleus, 50 were identified as primary and secondary input vagus neurons. Single stimuli applied to the septal nuclei induced initial excitation in 30% (15 units) of vagus neurons. The latent period of these responses was 5-25 msec. Presentation of paired stimuli showed that loss of the ability to respond to the second stimulus occurred at interstimulus intervals of 10-200 and sometimes 300 msec. A total of 34% (17 units) of solitary tract nucleus neurons showed tonic changes in spontaneous activity in response to rhythmic stimulation. Increasing the stimulation frequency to 10-20 Hz led to very different changes in the spontaneous rhythm, i.e., wave-like changes (decreases and increases in frequency, secondary suppression) or complete inhibition, sometimes lasting up to 10 sec after stimulation ended. A small number of units (five) showed a blocking effect of septal discharges on the visceral afferent input in conditions of paired stimulation. These results lead to the conclusion that the LSN and BNST are involved in modulating the activity of bulbar viscerosensory neurons, though their influences are mediated mainly via oligo- and polysynaptic pathways via other limbic structures (hypothalamus, amygdala).
为了研究外侧隔核（LSN）和终纹床核（BNST）的单次、配对和频繁刺激对孤束核中内脏感觉神经元活动的下行影响，对用戊巴比妥和氯醛糖混合物麻醉的猫进行了研究，通过刺激迷走神经颈部来识别这些神经元。在孤束核中记录的70个单位中，50个被确定为初级和次级传入迷走神经神经元。对隔核施加单次刺激可使30%（15个单位）的迷走神经神经元产生初始兴奋。这些反应的潜伏期为5 - 25毫秒。配对刺激的呈现表明，在10 - 200毫秒，有时在300毫秒的刺激间隔下，对第二个刺激的反应能力丧失。总共34%（17个单位）的孤束核神经元在对节律性刺激的反应中表现出自发活动的紧张性变化。将刺激频率增加到10 - 20赫兹会导致自发节律产生非常不同的变化，即波形变化（频率降低和增加，继发性抑制）或完全抑制，有时在刺激结束后可持续长达10秒。少数单位（5个）在配对刺激条件下显示出隔核放电对内脏传入输入的阻断作用。这些结果得出结论，外侧隔核和终纹床核参与调节延髓内脏感觉神经元的活动，尽管它们的影响主要通过其他边缘结构（下丘脑、杏仁核）的寡突触和多突触途径介导。
