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线状局灶性弹性组织变性:一种罕见的真皮弹性组织变性的组织病理学诊断

Linear focal elastosis: histopathologic diagnosis of an uncommon dermal elastosis.

作者信息

Pui John C, Arroyo Martha, Heintz Patrick

机构信息

Ronald O. Perlman Department of Dermatology, New York University School of Medicine, 530 First Avenue, Suite 7J, New York, NY 10016, USA.

出版信息

J Drugs Dermatol. 2003 Jan;2(1):79-83.

Abstract

BACKGROUND

Linear focal elastosis is an uncommon dermal elastosis that occurs predominantly on the back. Although first described in the lumbar region of elderly white men, more recent reports note similar findings on the trunk and limbs of adolescent Asian men.

METHODS

We present a typical case of an eighty-three year old white man with a one-year history of asymptomatic linear yellow and erythematous plaques on his lumbar region.

RESULTS

Light microscopic examination revealed skin with an unremarkable epidermis with coarsely clumped elastic fibers in the reticular dermis, which were highlighted by an elastic tissue stain.

CONCLUSION

The histopathologic differential diagnosis includes pseudoxanthoma elasticum, connective tissue nevus, elastofibroma, and solar elastosis. Although some of these diagnoses can be excluded by histologic examination, correlation with the clinical findings is necessary to arrive at the correct diagnosis of linear focal elastosis. Linear focal elastosis is an uncommon dermal elastosis that was originally described as asymptomatic linear yellow plaques in the lumbar region in elderly white males 1. Recent reports have extended the spectrum of this entity to include red-yellow linear atrophic to raised plaques on the trunks and limbs of adolescent males, predominantly of Asian descent. Twenty-one cases of linear focal elastosis have been reported in the literature. We report an additional case of linear focal elastosis in an elderly male and review the literature.

摘要

背景

线状局灶性弹性组织变性是一种罕见的皮肤弹性组织变性,主要发生于背部。尽管最初是在老年白人男性的腰部区域被描述,但最近的报告指出,在青少年亚洲男性的躯干和四肢也有类似发现。

方法

我们报告了一例典型病例,一名83岁白人男性,腰部有无症状的线状黄色和红斑性斑块,病程1年。

结果

光镜检查显示,表皮无明显异常,网状真皮内弹性纤维粗集,弹性组织染色可使这些纤维更明显。

结论

组织病理学鉴别诊断包括弹性假黄瘤、结缔组织痣、弹力纤维瘤和日光性弹性组织变性。虽然通过组织学检查可以排除其中一些诊断,但必须结合临床发现才能正确诊断线状局灶性弹性组织变性。线状局灶性弹性组织变性是一种罕见的皮肤弹性组织变性,最初被描述为老年白人男性腰部无症状的线状黄色斑块[1]。最近的报告扩大了该疾病的范围,包括青少年男性(主要为亚洲裔)躯干和四肢上红黄相间的线状萎缩性至隆起性斑块。文献中已报道了21例线状局灶性弹性组织变性病例。我们报告了另一例老年男性线状局灶性弹性组织变性病例并对文献进行了综述。

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