Aung Tim, Noakes Rowland, Kasem Kais, Murrell Dedee F
Bond University, Gold Coast, Queensland, Australia.
University of Queensland, Brisbane, Queensland, Australia.
Australas J Dermatol. 2025 Sep;66(6):364-368. doi: 10.1111/ajd.14569. Epub 2025 Jul 18.
Linear focal elastosis (LFE), characterised by horizontal streaks on the lower back, is a dermatological condition with unclear etiopathogenesis and limited epidemiological data. This study synthesises case reports to elucidate demographic patterns, clinical manifestations, and potential associations. A literature search across PubMed, Embase, Ovid and ResearchGate identified 37 relevant articles, yielding 80 cases after excluding duplicates and irrelevant articles. In analysis, the male-to-female ratio for LFE was 5:1, with a mean age of 39 years. Cases were more common among adolescents and older adults (age ≥ 60), with the majority occurring in pubertal adolescents. No racial predilection was observed. The lower back was the most frequently affected site, with rare cases involving other body parts. Some cases were associated with growth spurts or strenuous exercise, although the etiopathogenesis remains speculative. LFE may be underreported due to its asymptomatic nature and resemblance to other skin conditions, particularly striae distensae. Further research is required to clarify its pathogenesis and explore potential treatment options.
线状局灶性弹性组织变性(LFE)以下背部出现水平条纹为特征,是一种病因发病机制不明且流行病学数据有限的皮肤病。本研究综合病例报告以阐明人口统计学模式、临床表现及潜在关联。通过对PubMed、Embase、Ovid和ResearchGate进行文献检索,共识别出37篇相关文章,排除重复及无关文章后得到80例病例。分析显示,LFE的男女比例为5:1,平均年龄为39岁。病例在青少年和老年人(年龄≥60岁)中更为常见,大多数发生在青春期青少年。未观察到种族倾向。下背部是最常受累的部位,极少数病例累及身体其他部位。部分病例与生长突增或剧烈运动有关,但其病因发病机制仍属推测。由于LFE无症状且与其他皮肤疾病(尤其是膨胀纹)相似,可能存在报告不足的情况。需要进一步研究以阐明其发病机制并探索潜在的治疗方案。