Sagerman P M, Relman D A, Niroomand F, Niedt G W
Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Diagn Mol Pathol. 1992 Sep;1(3):212-6.
We report a 39-year-old man who had AIDS and who presented with an unusual cutaneous vascular lesion, which was clinically thought to be Kaposi's sarcoma. Histologically, the lesion was characterized by capillary proliferation and a mixed inflammatory infiltrate that included numerous histiocytes. The lesion was found to contain slender intracellular acid-fast bacilli, as well as plump extracellular Warthin-Starry-positive bacilli. The acid-fast bacilli were confirmed to be Mycobacterium avium-intracellulare by subsequent positive blood cultures for this organism. To further investigate the lesion, polymerase chain reaction DNA amplification and sequencing was performed, and the lesion was found to contain DNA sequences identical to those previously established for the agent of bacillary angiomatosis. The lesion is thought to represent a lesion of bacillary angiomatosis with secondary involvement by M. avium-intracellulare.
我们报告了一名39岁患有艾滋病的男性，他出现了一种不寻常的皮肤血管病变，临床上认为是卡波西肉瘤。组织学上，该病变的特征是毛细血管增生和混合性炎症浸润，其中包括大量组织细胞。发现该病变含有细长的细胞内抗酸杆菌，以及丰满的细胞外沃辛-斯塔里阳性杆菌。随后该病原体的血培养呈阳性，证实这些抗酸杆菌为鸟分枝杆菌-胞内分枝杆菌。为了进一步研究该病变，进行了聚合酶链反应DNA扩增和测序，发现该病变含有与先前确定的杆菌性血管瘤病原体相同的DNA序列。该病变被认为代表了伴有鸟分枝杆菌-胞内分枝杆菌继发感染的杆菌性血管瘤病变。
