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Synthesis of an amphiphilic tetraantennary mannosyl conjugate and incorporation into liposome carriers.

作者信息

Espuelas Socorro, Haller Philippe, Schuber Francis, Frisch Benoît

机构信息

Laboratoire de Chimie Bioorganique, UMR 7514 CNRS/ULP, Université Louis Pasteur, Faculté de Pharmacie, 74 route du Rhin, 67400-Illkirch, France

出版信息

Bioorg Med Chem Lett. 2003 Aug 4;13(15):2557-60. doi: 10.1016/s0960-894x(03)00472-4.

DOI:10.1016/s0960-894x(03)00472-4
PMID:12852965
Abstract

We have synthesized a novel conjugate (Man(4)K(3)DOG) composed of a tetramannosyl head group connected, via a polyethylene glycol spacer, to a lipid moiety. This amphiphilic molecule was easily incorporated into the bilayers of liposomes. As expected from the clustering effect, such multivalent mannose residues when exposed on the surface of the vesicles showed much higher binding affinity for Concanavalin A than their monomannosyl analogue. Mannosylated liposomes prepared with the tetravalent antenna could be promising carriers for e.g., loading dendritic cells with antigens for vaccination purposes.

摘要

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