Fourré F, Barbason H
Service de mathématiques appliquées, institut d'électricité Montefiore (B28), université de Liège, 4000 Liège, Belgique.
Pathol Biol (Paris). 2003 Jun;51(4):225-6. doi: 10.1016/s0369-8114(03)00028-2.
Carcinogenesis is generally viewed as the result of a disrupted equilibrium between the processes of proliferation, differentiation, migration and loss. In cell kinetics, perturbation of fundamental kinetic parameters such as the mitotic index or the growth fraction may reflect a carcinogenic process. In this paper, we present a system of deterministic differential equations describing the dynamical evolution of a cell population. We show that this model can account for asynchronicity of cells and simulate the fraction of labelled mitoses experiment as well.
致癌作用通常被视为增殖、分化、迁移和凋亡过程之间平衡被破坏的结果。在细胞动力学中,诸如有丝分裂指数或生长分数等基本动力学参数的扰动可能反映致癌过程。在本文中,我们提出了一个描述细胞群体动态演化的确定性微分方程系统。我们表明,该模型可以解释细胞的异步性,并模拟标记有丝分裂实验的分数。