Nagaki K, Inai S
Int Arch Allergy Appl Immunol. 1976;50(2):172-80. doi: 10.1159/000231494.
Acidic mucopolysaccharides enhanced C1INA activity against C1s. The presence of heparin in the reaction mixture of C1INA and C1s markedly enhanced the inactivation of C1s by potentiating C1INA activity. Treatment of serum with C1s resulted in the inactivation of C4 hemolytic activity, but this inactivation of C4 by C1s was prevented by the presence of heparin presumably due to the enhancement of C1INA activity normally present in serum. The other acidic mucopolysaccharides, chondroitin sulfates A, B and C, were also effective on potentiating C1INA activity against C1s, but they were less active than heparin. The enhancement of C1INA activity by heparin was not observed in the reaction between C1INA and plasmin.
酸性粘多糖增强了C1抑制物（C1INA）对C1s的活性。在C1INA与C1s的反应混合物中存在肝素，通过增强C1INA的活性显著增强了C1s的失活。用C1s处理血清导致C4溶血活性失活，但肝素的存在可防止C1s对C4的这种失活，推测这是由于血清中正常存在的C1INA活性增强所致。其他酸性粘多糖，硫酸软骨素A、B和C，对增强C1INA对C1s的活性也有效，但它们的活性比肝素低。在C1INA与纤溶酶的反应中未观察到肝素对C1INA活性的增强作用。
