Orofino Maria Grazia, Argiolu Francesca, Sanna Maria Adele, Rosatelli Maria Cristina, Tuveri Teresa, Scalas Maria Teresa, Badiali Manuela, Cossu Paola, Puddu Rosalba, Lai Maria Eliana, Cao Antonio
Universita degli Studi di Cagliari, Department of Biomedical Science and Biotechnology, Paediatric Clinic of the Bone Marrow Transplant Centre, Cagliari, Italy.
Lancet. 2003 Jul 5;362(9377):41-2. doi: 10.1016/S0140-6736(03)13806-8.
Stem-cell transplantation can cure beta thalassaemia. We aimed to assess whether fetal HLA typing done early in the pregnancy of couples who were at risk of beta thalassaemia could provide an alternative to pregnancy termination if the prospect of a bone-marrow transplantation from a family member was available. In our clinic in Sardinia, we did fetal HLA typing for 49 couples at risk of having a baby with beta thalassaemia. Two affected children were born and successfully received a transplantation from a family donor. Five non-affected fetuses were HLA compatible with an affected sibling and their cord blood was harvested for a future transplantation.
干细胞移植可以治愈β地中海贫血。我们旨在评估，对于有β地中海贫血风险的夫妇，在孕期早期进行胎儿HLA分型，如果有家庭成员进行骨髓移植的可能性，是否可以替代终止妊娠。在我们位于撒丁岛的诊所，我们对49对有生育β地中海贫血患儿风险的夫妇进行了胎儿HLA分型。两名患病儿童出生，并成功接受了来自家庭供体的移植。五名未患病胎儿与患病同胞HLA配型相合，他们的脐带血被采集以备将来移植。
