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Singling out genetic disorders and disease.单基因疾病和遗传疾病。
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本文引用的文献

1
Preimplantation HLA testing.植入前HLA检测
JAMA. 2004 May 5;291(17):2079-85. doi: 10.1001/jama.291.17.2079.
2
Novel universal approach for preimplantation genetic diagnosis of beta-thalassaemia in combination with HLA matching of embryos.用于β地中海贫血胚胎植入前基因诊断并结合胚胎HLA配型的新型通用方法。
Hum Reprod. 2004 Mar;19(3):700-8. doi: 10.1093/humrep/deh153. Epub 2004 Jan 29.
3
Hematopoietic stem cell transplantation using umbilical cord blood progenitors: review of current clinical results.使用脐带血祖细胞进行造血干细胞移植:当前临床结果综述
Bone Marrow Transplant. 2004 Apr;33(7):675-90. doi: 10.1038/sj.bmt.1704405.
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Using preimplantation genetic diagnosis to create a stem cell donor: issues, guidelines & limits.
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Current status of preimplantation diagnosis for single gene disorders.
Reprod Biomed Online. 2003 Sep;7(2):145-50. doi: 10.1016/s1472-6483(10)61744-0.
6
Fetal HLA typing in beta thalassaemia: implications for haemopoietic stem-cell transplantation.β地中海贫血中的胎儿HLA分型:对造血干细胞移植的意义。
Lancet. 2003 Jul 5;362(9377):41-2. doi: 10.1016/S0140-6736(03)13806-8.
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Preparing children to be bone marrow donors.
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The value of children: theory and method.儿童的价值:理论与方法。
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Hastings Cent Rep. 2002 May-Jun;32(3):34-40.

植入前HLA分型:通过生育来拯救我们所爱的人。

Preimplantation HLA typing: having children to save our loved ones.

作者信息

Devolder K

机构信息

Ghent University, Centre for Environmental Philosophy and Bioethics, Blandijnberg 2, B-9000 Gent, Belgium.

出版信息

J Med Ethics. 2005 Oct;31(10):582-6. doi: 10.1136/jme.2004.010348.

DOI:10.1136/jme.2004.010348
PMID:16199599
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1734026/
Abstract

Preimplantation tissue typing has been proposed as a method for creating a tissue matched child that can serve as a haematopoietic stem cell donor to save its sick sibling in need of a stem cell transplant. Despite recent promising results, many people have expressed their disapproval of this method. This paper addresses the main concerns of these critics: the risk of preimplantation genetic diagnosis (PGD) for the child to be born; the intention to have a donor child; the limits that should be placed on what may be done to the donor child, and whether the intended recipient can be someone other than a sibling. The author will show that these concerns do not constitute a sufficient ground to forbid people to use this technique to save not only a sibling, but also any other loved one's life. Finally, the author briefly deals with two alternative scenarios: the creation of a human leukocyte antigen (HLA) matched child as an insurance policy, and the banking of HLA matched embryos.

摘要

植入前组织配型已被提议作为一种方法,用于孕育一个组织匹配的孩子,该孩子可作为造血干细胞供体,以挽救其需要干细胞移植的患病同胞。尽管最近取得了一些令人鼓舞的成果,但许多人已表达了对这种方法的反对意见。本文探讨了这些批评者的主要担忧:对即将出生的孩子进行植入前基因诊断(PGD)的风险;生育一个供体孩子的意图;对供体孩子所能采取措施的限制,以及预期受体是否可以是同胞以外的其他人。作者将表明,这些担忧并不构成禁止人们使用这项技术来挽救不仅是同胞,而且是任何其他亲人生命的充分理由。最后,作者简要探讨了两种替代方案:将孕育一个人类白细胞抗原(HLA)匹配的孩子作为一种保障措施,以及储存HLA匹配的胚胎。