实验性免疫复合物性肾小球病：免疫形态学方面及其与人类疾病的相关性。

Experimental immune complex glomerulopathy: immunomorphological aspects and correlations with human disease.

作者信息

Rossmann P, Ríha I, Hajdu I

出版信息

Int Urol Nephrol. 1975;7(3):219-33. doi: 10.1007/BF02082678.

DOI:10.1007/BF02082678

Abstract

Thirteen rabbits received parenteral injections of human serum albumin (HSA) in regular doses and intervals during 6-32 seeks. The antigen load elicited immune responses of variable degree, giving a good correlation with the extent and quality of immune complex (IMC) deposition, as shown by immunological methods, electron and fluorescence microscopy and by histoautoradiography. Morphology of immune deposits (IMD) depended on the composition of the IMC and produced a continuous scale of glomerular involvement, ranging from minimal and focal to massive and diffuse deposition. Probable rudimentary traces of IMD were apparent in the ultrastructure even in animals with negative results of both immunological and immunfluorescence examinations. The relationships are discussed between experimental IMC-induced glomerulopathy on the one hand, and some problems of development and bioptic evaluation of human glomerulonephritis.

摘要

13只兔子在6 - 32周期间按常规剂量和间隔接受人血清白蛋白（HSA）的肠胃外注射。抗原负荷引发了不同程度的免疫反应，与免疫复合物（IMC）沉积的范围和质量具有良好的相关性，这通过免疫学方法、电子显微镜和荧光显微镜以及组织放射自显影得以证明。免疫沉积物（IMD）的形态取决于IMC的组成，并产生了一系列连续的肾小球受累情况，范围从最小和局灶性到大量和弥漫性沉积。即使在免疫学和免疫荧光检查结果均为阴性的动物中，IMD的可能基本痕迹在超微结构中也很明显。本文讨论了一方面实验性IMC诱导的肾小球病与人类肾小球肾炎发展和活检评估的一些问题之间的关系。