肺出血肾炎综合征——抗体在肾小球基底膜的局部及弥漫性沉积。病例报告。
Goodpasture's syndrome--local and diffuse deposition of antibody in glomerular basement membrane. Case report.
作者信息
Tomaszewski M M, Hassell L H, Moore J, Antonovych T T
出版信息
Clin Nephrol. 1983 Jul;20(1):44-8.
PMID:6224622
Abstract
An unusual case of Goodpasture's syndrome in a 22 year old white female is presented. The diagnosis of antiglomerular basement membrane disease was made on the basis of circulating anti-GBM antibodies in the presence of linear IgG deposits along the glomerular basement membrane by immunofluorescent microscopy. An additional finding was the presence of discrete granular subepithelial deposits on electron microscopy. Possible pathogenetic mechanisms are discussed.
摘要
本文报告了一例22岁白人女性患Goodpasture综合征的罕见病例。抗肾小球基底膜病的诊断基于循环抗GBM抗体的存在以及免疫荧光显微镜检查显示沿肾小球基底膜有线性IgG沉积。另一项发现是电子显微镜下可见离散的颗粒状上皮下沉积物。文中讨论了可能的发病机制。
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