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免疫复合物性急性血清病肾小球肾炎致病因素的实验研究。II. 病理形态学分析。

Experimental studies on factors causing acute serum sickness glomerulonephritis of immune complex origin. II. Pathomorphological analysis.

作者信息

Szabó J, Szabó T, Lustyik G, Lenkey A

出版信息

Int Urol Nephrol. 1977;9(3):267-81. doi: 10.1007/BF02082174.

DOI:10.1007/BF02082174
PMID:608822
Abstract

Seventeen rabbits were given a single, large dose of bovine serum albumin (BSA) intravenously. Percutaneous kidney biopsy was carried out on the 14th and 31st days after BSA administration. Proteinuria was measured and the glomerular changes were analysed in order to find a correlation between the degree of proteinuria and glomerular alterations, i.e. number of electron-dense deposits (EDD), polymorphonuclear leukocytes (PMNL), and mononuclear marcophages (MNM). The results speak in favour of the decisive role of mononuclear macrophages in enhancement of glomerular permeability.

摘要

给17只兔子静脉注射单次大剂量牛血清白蛋白(BSA)。在注射BSA后的第14天和第31天进行经皮肾活检。测量蛋白尿,并分析肾小球变化,以找出蛋白尿程度与肾小球改变之间的相关性,即电子致密沉积物(EDD)、多形核白细胞(PMNL)和单核巨噬细胞(MNM)的数量。结果表明单核巨噬细胞在增强肾小球通透性方面起决定性作用。

相似文献

1
Experimental studies on factors causing acute serum sickness glomerulonephritis of immune complex origin. II. Pathomorphological analysis.免疫复合物性急性血清病肾小球肾炎致病因素的实验研究。II. 病理形态学分析。
Int Urol Nephrol. 1977;9(3):267-81. doi: 10.1007/BF02082174.
2
Relationship of proteinuria to glomerular basement membrane deposits in serum-sickness glomerulonephritis in rabbits.兔血清病肾小球肾炎中蛋白尿与肾小球基底膜沉积物的关系。
Vet Pathol. 1977 Sep;14(5):482-9. doi: 10.1177/030098587701400508.
3
Studies on passive serum sickness. I. The glomerular fine structure of serum sickness nephritis induced by preformed antigen-antibody complexes in the mouse.被动血清病研究。I. 小鼠中预先形成的抗原-抗体复合物诱导的血清病肾炎的肾小球精细结构
Lab Invest. 1971 May;24(5):383-91.
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Experimental studies on factors causing acute serum sickness glomerulonephritis of immune complex origin. I. The role of immune complexes and the immunological status of the host.免疫复合物性急性血清病肾小球肾炎致病因素的实验研究。I. 免疫复合物的作用及宿主的免疫状态。
Int Urol Nephrol. 1977;9(3):255-65. doi: 10.1007/BF02082173.
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Participation of monocytes in glomerulonephritis in acute serum sickness of rabbit.单核细胞在兔急性血清病肾小球肾炎中的参与情况。
Acta Pathol Jpn. 1976 Jul;26(4):423-33. doi: 10.1111/j.1440-1827.1976.tb00500.x.
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Chronic serum sickness glomerulonephritis: passive immunisation inhibits the removal of glomerular antigen and electron dense deposits.慢性血清病性肾小球肾炎:被动免疫抑制肾小球抗原及电子致密沉积物的清除。
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Localization of cationic proteins derived from platelets and polymorphonuclear neutrophils and local loss of anionic sites in glomeruli of rabbits with experimentally-induced acute serum sickness.实验性诱导急性血清病兔肾小球中血小板和多形核中性粒细胞来源的阳离子蛋白定位及阴离子位点局部缺失
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Acute serum sickness in normal and C6 deficient rabbits: role of membrane attack complex.正常及C6缺陷兔的急性血清病:膜攻击复合物的作用
Int J Exp Pathol. 1992 Jun;73(3):299-312.

引用本文的文献

1
Experimental glomerular lesions induced by chronic immune complex formation. II. Pathomorphological analysis.慢性免疫复合物形成诱导的实验性肾小球病变。II. 病理形态学分析。
Int Urol Nephrol. 1979;11(2):127-43. doi: 10.1007/BF02082233.
2
Granulomatous glomerulonephritis, without systemic disorder.肉芽肿性肾小球肾炎,无全身疾病。
Virchows Arch A Pathol Anat Histol. 1978 Dec 12;381(1):111-9. doi: 10.1007/BF00433490.

本文引用的文献

1
Mechanisms involved in the deposition of immune complexes in tissues.免疫复合物在组织中沉积的机制。
J Exp Med. 1971 Sep 1;134(3):75-89.
2
Quantitation of acute and chronic serum sickness in the rabbit.兔急性和慢性血清病的定量研究。
J Exp Med. 1971 Sep 1;134(3):7-18.
3
Analytical pathology. II. Histopathologic demonstration of glomerular-localizing antibodies in experimental glomerulonephritis.分析病理学。II. 实验性肾小球肾炎中肾小球定位抗体的组织病理学证明。
Am J Pathol. 1955 Jul-Aug;31(4):687-715.
4
A ROLE OF POLYMORPHONUCLEAR LEUKOCYTES AND COMPLEMENT IN NEPHROTOXIC NEPHRITIS.多形核白细胞和补体在肾毒性肾炎中的作用
J Exp Med. 1965 Jul 1;122(1):99-116. doi: 10.1084/jem.122.1.99.
5
Experimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis.实验性肾小球肾炎。一种类似于人类肾小球肾炎谱系的实验室模型的发病机制。
J Exp Med. 1961 May 1;113(5):899-920. doi: 10.1084/jem.113.5.899.
6
Electron microscopy of serum sickness nephritis.血清病性肾炎的电子显微镜检查
J Exp Med. 1958 Dec 1;108(6):957-62. doi: 10.1084/jem.108.6.957.
7
Pathogenesis of serum sickness.血清病的发病机制。
AMA Arch Pathol. 1958 Jan;65(1):18-28.
8
A comparative histologic and immunologic study in rabbits of induced hypersensitivity of the serum sickness type.兔血清病型诱导超敏反应的组织学和免疫学对比研究
J Exp Med. 1953 Feb 1;97(2):257-82. doi: 10.1084/jem.97.2.257.
9
Acute serum sickness nephritis in the rabbit. An immune deposit disease.兔急性血清病肾炎。一种免疫沉积病。
Am J Pathol. 1966 Dec;49(6):997-1022.
10
[On methods of percutaneous renal biopsy in rabbits].[关于家兔经皮肾活检的方法]
Acta Biol Med Ger. 1965;15(4):492-9.