Menke D M, Camoriano J K, Banks P M
Section of Pathology, Mayo Clinic Jacksonville, Florida.
Mod Pathol. 1992 Sep;5(5):525-30.
A morphometric and clinical analysis of 47 cases of angiofollicular lymph node hyperplasia (AFLH) demonstrated morphometric differences between plasma cell (28 cases) and hyaline vascular (19 cases) AFLH. Twenty-one AFLH cases were unicentric, and 26 cases were multicentric. Plasma cell types of AFLH, defined by standard morphologic and objective morphometric assessment, were associated with systemic clinical and laboratory abnormalities. Unicentric or hyaline vascular AFLH was amenable to surgical therapy, and multicentric or plasma cell AFLH without neuropathy was amenable to steroid treatment or chemotherapy with good prognoses. Multicentric or plasma cell AFLH with neuropathy was associated with resistance to steroids and chemotherapy and with a poor prognosis.
对47例血管滤泡性淋巴结增生（AFLH）进行的形态计量学和临床分析显示，浆细胞型（28例）和透明血管型（19例）AFLH之间存在形态计量学差异。21例AFLH为单中心性，26例为多中心性。通过标准形态学和客观形态计量学评估定义的浆细胞型AFLH与全身临床和实验室异常相关。单中心性或透明血管型AFLH适合手术治疗，多中心性或无神经病变的浆细胞型AFLH适合类固醇治疗或化疗，预后良好。多中心性或伴有神经病变的浆细胞型AFLH与对类固醇和化疗的耐药性相关，预后较差。
