Sassani Joseph W, Zagon Ian S, McLaughlin Patricia J
Department of Ophthalmology, Penn State's Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA.
Curr Eye Res. 2003 May;26(5):249-62. doi: 10.1076/ceyr.26.4.249.15427.
This paper presents a concise review of the role of the intrinsic opioid growth regulation system (IOGRS) in homeostasis and wound repair of the corneal epithelium.
The article is a summary of published research on the topic.
The native opioid peptide, [Met(5)]-enkephalin, also termed opioid growth factor (OGF), has been demonstrated to be present in a wide variety of classes of the phylum. Chordata, and acts as an autocrine/paracrine produced, tonically active, receptor specific, negative growth modulating factor in homeostatic (uninjured) corneal epithelium in humans and non-primates. Similarly, OGF acts to down-regulate epithelial cell division and migration of corneal epithelium in the closing of corneal epithelial abrasions. Such repair can be up-regulated (hastened) in non-diabetic animals by treatment with exogenous administration of the potent opioid antagonist, naltrexone (NTX). The system also is functional in diabetic animals and can be manipulated to restore epithelial wound healing rates to normal.
The IOGRS plays a vital role in supporting corneal epithelial homeostasis, and in modulating closure of epithelial wounds. The system should provide opportunities for novel therapies especially for corneal epithelial wound healing disorders.
本文简要综述内源性阿片样物质生长调节系统（IOGRS）在角膜上皮稳态和伤口修复中的作用。
本文是关于该主题已发表研究的总结。
天然阿片肽[Met(5)]-脑啡肽，也称为阿片样生长因子（OGF），已被证明存在于脊索动物门的多种类别中，并在人类和非灵长类动物的稳态（未受伤）角膜上皮中作为自分泌/旁分泌产生的、具有张力活性的、受体特异性的负生长调节因子发挥作用。同样，在角膜上皮擦伤愈合过程中，OGF可下调角膜上皮细胞的分裂和迁移。在非糖尿病动物中，通过外源性给予强效阿片拮抗剂纳曲酮（NTX）可上调（加速）这种修复。该系统在糖尿病动物中也有功能，并且可以通过调节使其上皮伤口愈合速度恢复正常。
IOGRS在维持角膜上皮稳态以及调节上皮伤口闭合方面起着至关重要的作用。该系统应为新型治疗方法提供机会，尤其是针对角膜上皮伤口愈合障碍的治疗。
