创伤角膜以了解其愈合过程。
Wounding the cornea to learn how it heals.
机构信息
Department of Anatomy and Regenerative Biology, The George Washington University Medical Center, Washington, DC 20037, USA; Department of Ophthalmology, The George Washington University Medical Center, Washington, DC 20037, USA.
Department of Ophthalmology, Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114-2500, USA.
出版信息
Exp Eye Res. 2014 Apr;121:178-93. doi: 10.1016/j.exer.2014.02.007. Epub 2014 Mar 4.
Corneal wound healing studies have a long history and rich literature that describes the data obtained over the past 70 years using many different species of animals and methods of injury. These studies have lead to reduced suffering and provided clues to treatments that are now helping patients live more productive lives. In spite of the progress made, further research is required since blindness and reduced quality of life due to corneal scarring still happens. The purpose of this review is to summarize what is known about different types of wound and animal models used to study corneal wound healing. The subject of corneal wound healing is broad and includes chemical and mechanical wound models. This review focuses on mechanical injury models involving debridement and keratectomy wounds to reflect the authors' expertise.
角膜创伤愈合的研究历史悠久，文献丰富，描述了过去 70 年来使用许多不同物种的动物和损伤方法获得的数据。这些研究减轻了患者的痛苦，并为目前帮助患者过上更有成效的生活的治疗方法提供了线索。尽管取得了进展，但仍需要进一步的研究，因为由于角膜瘢痕形成导致的失明和生活质量下降仍然存在。本综述的目的是总结关于不同类型的伤口和用于研究角膜创伤愈合的动物模型的已知内容。角膜创伤愈合的主题很广泛，包括化学和机械创伤模型。本综述侧重于反映作者专业知识的机械损伤模型，包括清创术和角膜切除术伤口。
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