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[术中应用丝裂霉素C和羊膜移植治疗复发性翼状胬肉的手术效果]

[Outcome of surgery for recurrent pterygium using intraoperative application of mitomycin C and amniotic membrane transplantation].

作者信息

Kawasaki Shiro, Uno Toshihiko, Shimamura Ichiro, Ohashi Yuichi

机构信息

Department of Ophthalmology, Ehime University School of Medicine, Shitsukawa, Shigenobu-cho, Onsen-gun, Ehime 791-0295, Japan.

出版信息

Nippon Ganka Gakkai Zasshi. 2003 Jun;107(6):316-21.

Abstract

PURPOSE

Preserved human amniotic membrane has been used in reconstruction of the ocular surface. In this paper, we report our method of amniotic membrane transplantation (AMT) for recurrent pterygium.

METHODS

Twenty-six eyes of 26 patients with recurrent pterygium are reported. All subjects were operated on with an extensive excision of the subconjunctival fibrous tissues followed by application of mitomycin C (0.04%, 3-5 min) during the operation. Amniotic membrane transplantation was performed with implantation of conjunctival autograft in cases with a large excision.

RESULTS

The mean follow up time was 17.3 +/- 9.3 (mean +/- standard deviation) months. Twelve eyes showed severe symblepharon and 14 patients suffered from double vision before the operation. There were only three mild recurrences (12%), 11 patients recovered from double vision, and no major complications such as sclermalasia were noted during the follow-up period.

CONCLUSION

AMT with application of mitomycin C is effective in preventing pterygium recurrence and for improved ocular movement. The cosmetic outcome of our methods has also been satisfactory.

摘要

目的

保存的人羊膜已用于眼表重建。在本文中,我们报告了我们用于复发性翼状胬肉的羊膜移植(AMT)方法。

方法

报告了26例复发性翼状胬肉患者的26只眼。所有患者均接受手术,广泛切除结膜下纤维组织,术中应用丝裂霉素C(0.04%,3 - 5分钟)。对于切除范围较大的病例,在羊膜移植的同时植入结膜自体移植片。

结果

平均随访时间为17.3±9.3(平均值±标准差)个月。术前12只眼有严重睑球粘连,14例患者有复视。随访期间仅3例轻度复发(12%),11例患者复视恢复,未发现巩膜软化等严重并发症。

结论

应用丝裂霉素C的羊膜移植在预防翼状胬肉复发和改善眼球运动方面有效。我们方法的美容效果也令人满意。

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