Góes V R V, Sartori M G F, Baracat E C, Rodrigues de Lima G, Girão M J B C
Gynecology Department, Federal University of São Paulo, Brazil.
Clin Exp Obstet Gynecol. 2003;30(2-3):103-6.
The purpose [corrected] of this study was to evaluate the effects of isolated cyclic estrogen therapy in menopausal women with stress urinary incontinence, and thus without the effects of progesterone.
Nineteen menopausal patients with stress urinary incontinence were selected and submitted to anamnesis and physical, gynecological and urodynamic examinations. The group was homogeneous in relation to parity, body mass index and degree of urogenital prolapse. All the patients received conjugated equine estrogens orally, at a dose of 0.625 mg, for 21 days each month. After three months the clinical and urodynamic evaluations in relation to urine loss, were performed again.
Of the patients 57.9% were satisfied with the treatment. The urodynamic parameters remained unaltered in 36.85% of the patients.
Our results show that estrogen is important for stress urinary incontinence in postmenopause, specially in patients without cystocele or with cystocele of degree I or II.
本研究的目的是评估单纯循环雌激素疗法对绝经后压力性尿失禁女性的影响，从而排除孕激素的作用。
选取19例绝经后压力性尿失禁患者，进行病史采集及体格、妇科和尿动力学检查。该组患者在产次、体重指数和泌尿生殖器官脱垂程度方面具有同质性。所有患者每月口服共轭马雌激素，剂量为0.625毫克，共21天。三个月后，再次进行与尿失禁相关的临床和尿动力学评估。
57.9%的患者对治疗满意。36.85%的患者尿动力学参数未发生改变。
我们的结果表明，雌激素对绝经后压力性尿失禁很重要，特别是对于没有膀胱膨出或有I度或II度膀胱膨出的患者。
