用结合雌激素加孕激素治疗绝经后真性压力性尿失禁。
Menopausal genuine stress urinary incontinence treated with conjugated estrogens plus progestogens.
作者信息
Sartori M G, Baracat E C, Girão M J, Gonçalves W J, Sartori J P, de Lima G R
机构信息
Discipline of Gynecology, Escola Paulista de Medicina, São Paulo Hospital, Brazil.
出版信息
Int J Gynaecol Obstet. 1995 May;49(2):165-9. doi: 10.1016/0020-7292(95)02358-j.
OBJECTIVE
The aim of the study was to investigate clinically and urodynamically the effects of hormonal replacement in the treatment of genuine stress urinary incontinence in postmenopausal females.
METHODS
Clinical and urodynamic variables of 30 postmenopausal women with genuine stress urinary incontinence were evaluated after 3 months' treatment with conjugated estrogens plus progestogens. Urodynamic evaluations were performed in all patients before and after treatment.
RESULTS
Forty-six percent of the patients treated medically were judged to be cured and 43% were judged to be markedly improved. Maximum urethral closure pressure, maximum cystometric capacity and mean flow were significantly increased. Residual urine and diurnal and nocturnal voluntary micturition were markedly decreased (P < 0.05).
CONCLUSION
We conclude that hormone replacement in the form of conjugated estrogens plus progestogens results in the clinical and urodynamic improvement of genuine stress urinary incontinence in postmenopausal women.
目的
本研究旨在从临床和尿动力学方面调查激素替代疗法对绝经后女性真性压力性尿失禁的治疗效果。
方法
对30例绝经后真性压力性尿失禁女性患者采用结合雌激素加孕激素治疗3个月后，评估其临床和尿动力学变量。所有患者在治疗前后均进行尿动力学评估。
结果
药物治疗的患者中，46%被判定治愈，43%被判定明显改善。最大尿道闭合压、最大膀胱测压容量和平均尿流率显著增加。残余尿量以及日间和夜间自主排尿量显著减少（P<0.05）。
结论
我们得出结论，结合雌激素加孕激素形式的激素替代疗法可使绝经后女性真性压力性尿失禁在临床和尿动力学方面得到改善。
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